Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Kunyit Putih (Curcuma Zedoaria Rosc.)
DOI:
https://doi.org/10.55606/jikki.v5i1.7054Keywords:
Chitosan, Floating, Microencapsulation, Sodium Alginate, White TurmericAbstract
This test aims to evaluate the formulation of floating microcapsule preparations containing ethanol extract of white turmeric (Curcuma zedoaria Rosc.), using chitosan, sodium alginate, and calcium chloride polymers as crosslinking agents. The preparation was formulated using the crosslinking method and tested based on its physical properties, which include moisture content, physical stability through cycle tests, resistance to the gastric and intestinal mucosa. The results showed that the microcapsule formulation was able to maintain the color and texture during the storage period well. The microcapsule durability test showed that the particles could survive in the gastric and intestinal mucosa for two hours. In addition, the water content is within the range that is in accordance with the requirements, namely, at a concentration of 0.25% there is (22%), a concentration of 0.5% there is (38.75%), a concentration of 0.75% there is (22.5%), and the blank has 20.5% water content. Based on previous research by Mardikasari et al., (2020) which used chitosan and alginate polymers. Through this method, this formulation shows the possibility as a technology-based drug delivery system that survives effectively in increasing the bioavailability of active substances from white turmeric.
References
Andini, S., Sa’diah, S., & Puspa, S. (2022). Preparasi dan karakteristik floating tablet ekstrak daun jambu biji (Psidium guajava L.) dengan variasi kombinasi xanthan gum dan HPMC. Jurnal Sains dan Kesehatan, 4(4), 370–378. https://doi.org/10.25026/jsk.v4i4.1226
Effect, T., Curcuma, T., & Dismutase, S. (2024). Pengaruh pemberian ekstrak kunyit putih (Curcuma zedoaria Rosc.) terhadap aktivitas superoksida dismutase (SOD). Medicamento, 10(2), 89–96. https://doi.org/10.36733/medicamento.v10i2.8498
Erwiyani, A. R., Sunnah, I., & Pratama, N. M. (2024). Formulation and evaluation of microcapsul of pumpkin (Cucurbita maxima D.) extract peel off gel mask formulasi dan evaluasi sediaan masker gel peel off mikrokapsul ekstrak labu kuning (Cucurbita maxima D.). Journal not specified, 11(3). (Perlu ditambahkan nama jurnal jika tersedia)
Hamidi, H., Nurokhman, A., Riswanda, J., Hiras Habisukan, U., Ulfa, K., Yachya, A., & Maryani, S. (2022). Identifikasi jenis tumbuhan family Zingiberaceae di Kebun Raya Sriwijaya Kabupaten Ogan Ilir Provinsi Sumatera Selatan. STIGMA: Jurnal Matematika dan Ilmu Pengetahuan Alam UNIPA, 15(02), 60–66. https://doi.org/10.36456/stigma.15.02.6273.60-66
Heriyanto, H. (2021). A review of encapsulation using emulsion crosslinking method. Journal not specified, 5(2), 37–43. (Perlu ditambahkan nama jurnal jika tersedia)
Hunafa, C. A., Nabila, D. D., Sari, D. N. I., Nurkhotimah, R., Lestari, M. A., Wahyudi, T., & Julaeha, E. (2021). Imobilisasi mikrokapsul antibakteri minyak asiri Eucalyptus globulus pada kain kapas dengan metode deep coating. Arena Tekstil, 36(2), 83–90. https://doi.org/10.31266/at.v36i2.7345
Indriaty, S., Karlina, N., Hidayati, N. R., Firmansyah, D., Senja, R. Y., & Zahiyah, Y. (2022). Formulasi dan uji aktivitas deodoran spray ekstrak etanol herba kemangi terhadap bakteri Staphylococcus aureus. Medical Sains: Jurnal Ilmiah Kefarmasian, 7(4), 973–982. https://doi.org/10.37874/ms.v7i4.566
Khanifah, F., & Vokasi, F. (2022). Uji flavonoid kunyit putih (Curcuma zedoaria) dan kunyit kuning (Curcuma longa) sebagai senyawa antibakteri Staphylococcus aureus. Prosiding Seminar Nasional Kimia, 1–7.
Mardikasari, S. A., Suryani, Akib, N. I., & Indahyani, R. (2020). Mikroenkapsulasi asam mefenamat menggunakan polimer kitosan dan natrium alginat dengan metode gelasi ionik. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 6(2), 192–203. https://doi.org/10.22487/j24428744.2020.v6.i2.14589
Maulida, M., Nurhasnawati, H., Sundu, R., Tinggi, S., & Kesehatan, I. (2025). Penetapan kadar fenolik total ekstrak etanol rimpang temu putih (Curcuma zedoaria (Berg.) Roscoe). Journal not specified, 7(1), 65–81. (Perlu ditambahkan nama jurnal jika tersedia)
Pertiwi, F. D., Rezaldi, F., & Puspitasari, R. (2022). Uji aktivitas dan formulasi sediaan liquid body wash dari ekstrak etanol bunga telang (Clitoria ternatea L.) sebagai antibakteri Staphylococcus epidermidis. Jurnal Ilmiah Kedokteran dan Kesehatan, 1(1), 53–66.
Primadevi, S., & Nafiah, R. (2020). Pengaruh crosslink agent pada pembuatan nanokitosan terhadap kadar flavonoid ekstrak etanol buah parijoto. Cendekia Journal of Pharmacy, 4(2), 156–168. https://doi.org/10.31596/cjp.v4i2.109
Santoso, R., & Aliudin, F. (2020). Kajian pustaka formulasi dan evaluasi mikrokapsul salut enterik menggunakan Acryl-Eze® & Sureteric dengan metode penggabungan mikroenkapsulasi dengan ekstrusi-sferonisasi. Jurnal Riset Kefarmasian Indonesia, 2(3), 122–136. https://doi.org/10.33759/jrki.v2i3.89
Saputri, N., & Nisa, M. (2021). Mikroenkapsulasi ekstrak buah buni sebagai food. Journal not specified, 1(2), 73–81. (Perlu ditambahkan nama jurnal jika tersedia)
Sari, D., Arza, S., Fiona, F., Novita, N., Dermawan, B., & Ega, E. (2024). Analisis kadar air dan nitrit pada pati sagu. Journal of Food Security and Agroindustry, 2(1), 11–16. https://doi.org/10.58184/jfsa.v2i1.280
Wahyuningsih, D., M., U. R. E., & Nugraheni, B. (2020). Uji aktivitas antioksidan mikrokapsul ekstrak limbah serabut kelapa sawit (Elaeis guineensis Jacq.) dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH). Media Farmasi Indonesia, 10(2), 928–939.
Wardatun, S., Rustiani, E., & Damahyanti, O. (2020). Pengembangan mikrogranul mukoadhesif ekstrak kayu manis dengan kombinasi polimer karbopol dan gelatin. Jurnal Fitofarmaka Indonesia, 7(1), 9–15. https://doi.org/10.33096/jffi.v7i1.477
Wati, R. R., Sriwidodo, S., & Chaerunisa, A. Y. (2022). Peningkatan stabilitas fitokonstituen melalui pendekatan mikroenkapsulasi. Majalah Farmasetika, 7(1), 39. https://doi.org/10.24198/mfarmasetika.v7i1.35265
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
