Evaluasi Drug Related Problems (DRPs) pada Pasien Penyakit Jantung di Poli Penyakit dalam RSU Royal Prima Marelan
DOI:
https://doi.org/10.55606/jikki.v5i1.6968Keywords:
Candesartan, Drug interaction, Drug related Problems (DRPs), Heart Disease, SpironolactoneAbstract
Heart disease is the leading cause of death in Indonesia. The use of complex drugs in the treatment of heart disease increases the risk of Drug Related Problems (DRPs), especially due to the many comorbidities and drug interactions. The purpose of this study was to determine the incidence of Drug Related Problems (DRPs) in heart disease patients at the internal medicine clinic of Royal Prima Marelan Hospital. This study is a retrospective descriptive study of 50 outpatients diagnosed with heart disease in the period January-June 2024. Data obtained from medical records and patient prescriptions were analyzed to identify the types of DRPs based on the PCNE classification. Drug interactions were the most prevalent type of DRP (95,7%), with severity levels classified as moderate (80,5%), minor (12,6%), and major (4,4%). The most frequent interactions occurred between clopidogrel and omeprazole (major). Most patients were male (60%) and aged between 40-55 years (54%).
References
Adiana, S., & Maulina, D. (2022). Fisioterapi kasus pneumonia pada anak. Indonesian Journal of Health Science, 2(1), 2020–2023.
Aisyah, Ranggauni Hardy, F., Pristya, T. Y., & Qoulan Karima, U. (2022). Kejadian penyakit jantung koroner pada pasien di RSUD Pasar Rebo. Higeia Journal of Public Health Research and Development, 6(4), 250–260. http://journal.unnes.ac.id/sju/index.php/higeia
Amrullah, S., Rosjidi, C. H., Dhesa, D. B., Wurjatmiko, A. T., & tim STIKes Karya Kesehatan. (n.d.). Faktor resiko penyakit infark miokard akut di Rumah Sakit Umum Dewi Sartika Kota Kendari. https://stikesks-kendari.e-journal.id/jikk
Arianto, E. (2020). Implememtasi metode Naive Bayes pada sistem pakar diagnosa penyakit arteriosklerosis. Informasi dan Teknologi Ilmiah (INTI), 7(2), 165–169. https://www.stmikbudidarma.ac.id/ejurnal/index.php/inti/article/view/2380
Baiden, I., Mendez, M., Xu, J., Liao, T., Maskey, D., & Ortiz, P. (2024). Loop diuretic resistance in a mouse model of cardiorenal syndrome. Physiology. https://doi.org/10.1152/physiol.2024.39.s1.1864
Berryhill, M. B., Halli-Tierney, A., Culmer, N., Williams, N., Betancourt, A., King, M., & Ruggles, H. (2019). Videoconferencing psychological therapy and anxiety: A systematic review. Family Practice, 36(1), 53–63. https://doi.org/10.1093/fampra/cmy072
Biletskyi, S. V., Sydorchuk, L., Petrynych, O. A., Казанцева, Т. В., Biletskyi, S. S., & Boyko, V. V. (2024). Diuretics in the treatment of chronic heart failure: Furosemide or torasemide (literature review). Bukovinsʹkij Medičnij Vìsnik, 28(2[110]), 137–141. https://doi.org/10.24061/2413-0737.28.2.110.2024.21
Dewi, N. M. A. R. (2020). Interaksi obat antara klopidogrel dan proton pump inhibitor (PPI). Sasambo Journal of Pharmacy, 1(1), 1–5. https://doi.org/10.29303/sjp.v1i1.12
Dipiro, J. T., Wells, B. G., Schwinghammer, T. L., & Dipiro, C. V. (2015). Pharmacotherapy handbook (9th ed., Section 4 Chapter 19). The McGraw-Hill Companies, Inc.
Effendi, F., & Harimu, H. B. (2022). Gambaran potensi interaksi obat antihipertensi oral (golongan ACE inhibitor dan angiotensin receptor blocker) pada pasien poli jantung RSUD Ciawi Bogor. Jurnal Kesehatan Mahardika, 8(2), 1–9. https://doi.org/10.54867/jkm.v8i2.59
Efriani, L., Irawan, A., & Anwar, M. (2024). Analisis drug related problems (DRPs) pada pasien angina pektoris RS X Kota Cirebon tahun 2023. Jurnal Farmasi, 13(2)
Fadlilah, S., Sucipto, A., & Amestiasih, T. (2019). Usia, jenis kelamin, perilaku merokok, dan IMT berhubungan dengan resiko penyakit kardiovaskuler. Jurnal Keperawatan, 11(4), 261–268. https://doi.org/10.32583/keperawatan.v11i4.558
Gafurova, N. M., Shikh, E. V., & Ostroumova, O. D. (2020). Current clinical and pharmacological approaches to the prescription of loop diuretics in patients with chronic heart failure. Rational Pharmacotherapy in Cardiology, 16(4), 595–600. https://doi.org/10.20996/1819-6446-2020-03-04
Galanti, K., Di Marino, M., Mansour, D., Testa, S., Rossi, D., Scollo, C., Magnano, R., Pezzi, L., D’Alleva, A., Forlani, D., Vitulli, P., Paloscia, L., Ricci, F., Renda, G., Gallina, S., & Di Marco, M. (2024). Current antithrombotic treatments for cardiovascular diseases: A comprehensive review. Reviews in Cardiovascular Medicine. https://doi.org/10.31083/j.rcm2508281
Habibie, B. Y. (2021). Terapi pada dispepsia. Jurnal Penelitian Perawat Profesional, 3(3), 503–510. https://doi.org/10.37287/jppp.v3i3.517
Hamdani, R., & Hasye, F. A. (2019). Efek latihan fisik terhadap remodeling jantung. Jurnal Kesehatan Andalas, 8(2), 427. https://doi.org/10.25077/jka.v8i2.1021
Hanutami, B., & Dandan, K. L. (2019). Identifikasi potensi interaksi antar obat pada resep umum di Apotek Kimia Farma 58 Kota Bandung bulan April 2019. Farmaka, 17(2), 57–64.
Hasanah, N., Fadly Putajaya, L. K., Nur Wulan Adi Ismaya, & Nanda Nurul Aini. (2021). Gambaran penyakit jantung berdasarkan demografi dan penggunaan obat. Jurnal Kesehatan, 10(1), 100–110. https://doi.org/10.37048/kesehatan.v10i1.311
Hasiholan, M. (2020). Penerapan metode LOG (Laplacian of Gaussian) dalam mendeteksi tepi citra pada penyakit aterosklerosis. Jurnal Pelita Informatika, 8(4), 435–438.
Hastutik, K. P. (2020). Hubungan tingkat pengetahuan dengan tekanan darah pada penderita hipertensi di ruang rawat inap RSUD Sultan Imanuddin Pangkalan Bun. (Laporan penelitian tidak dipublikasikan), 18.
Hidayat, N. (2023). Gambaran aktivitas fisik pasien penyakit jantung koroner (PJK) di Rumah Sakit Islam. (Laporan penelitian tidak dipublikasikan), 1–69.
Katimenta, K. Y., Rosela, K., & Rahman, T. (2023). Hubungan perilaku merokok dengan derajat keparahan aterosklerosis pada pasien penyakit jantung koroner. Jurnal Surya Medika, 9(1), 50–55. https://doi.org/10.33084/jsm.v9i1.5139
Kawengian, S., Wiyono, W. I., & Mamarimbing, M. (2019). Identifikasi drug related problems (DRPs) pada tahap administration pasien penyakit jantung koroner di instalasi rawat inap RSUP Prof. Dr. R. D. Kandou Manado. Pharmacon, 8(1), 1. https://doi.org/10.35799/pha.8.2019.29227
Khilya, S., Saheri, P., Penggunaan, S., Pada, F., Gagal, P., Di, J., & Sidoarjo, N. (2024). Studi penggunaan furosemide pada pasien gagal jantung di RSUD R.T. Notopuro Sidoarjo
Li, X., Weber, N. C., Cohn, D. M., Hollmann, M. W., DeVries, J. H., Hermanides, J., & Preckel, B. (2021). Effects of hyperglycemia and diabetes mellitus on coagulation and hemostasis. Journal of Clinical Medicine, 10(11), 2419. https://doi.org/10.3390/jcm10112419
Lie, J. G., Hansen, H., Fachriyah, A. S., & ... (2023). Peran proton pump inhibitor dalam mencegah terjadinya perdarahan saluran cerna pada pasien yang mengonsumsi antiplatelet. Jurnal Penelitian, 15. https://myjurnal.poltekkes.kdi.ac.id/index.php/hijp/article/view/942
Marzuqi, I. A., Studi, P., Farmasi, S., Kedokteran, F., Ilmu, D. A. N., Islam, U., Maulana, N., & Ibrahim, M. (2024). Anticholinergic burden pada pasien geriatri di Puskesmas Bululawang tahun 2024. (Judul jurnal belum lengkap).
Meidayanti, D. (2021). Manfaat likopen dalam tomat sebagai pencegahan terhadap timbulnya aterosklerosis. Jurnal Medika Hutama, 2(3), 2–6.
Nathaniela, J., Winarti, N. W., Sriwidyani, N. P., Dewi, I. G. A. S. M., & Henky. (2023). Karakteristik klinikopatologik aterosklerosis koroner dan morfologi. 12(12), 9–16.
Nyamagoud, S. B., Vishwanatha Swamy, A. H., Netalakar, A., Bhoomika, S. K., Namratha, D., & Kurabanavar, T. K. (2024). Identification of DRPs and assessment of health-related quality of life in cardiovascular patients in tertiary care teaching hospital. International Journal of Pharmaceutical Investigation. https://doi.org/10.5530/ijpi.14.2.55
Osmanska, J., Petrie, M. C., Docherty, K. F., Lee, M. M. Y., McMurray, J. J. V., & Campbell, R. T. (2024). Subcutaneous furosemide in heart failure: A systematic review. European Heart Journal - Cardiovascular Pharmacotherapy. https://doi.org/10.1093/ehjcvp/pvae083
Pambudi, R. S., & Helviana Rista, R. (2024). Potensi interaksi penggunaan obat antihipertensi di Klinik X Boyolali tahun 2023. Indonesian Journal of Pharmacy and Natural Product. https://doi.org/10.35473/ijpnp.v7i01.3045
PCNE. (2020). PCNE classification for drug-related problems V9.1. PCNE Association, 1(2), 22–28. http://www.pcne.org/upload/files/15_PCNE_classification_V4-00.pdf
Purmoni, I. S. (2021). Evaluasi drug related problems (DRPs) pada pengobatan pasien jantung koroner (PJK) di Puskesmas Deket Kabupaten Lamongan. Journal of Chemical Information and Modeling, 53(Februari), 2021. https://doi.org/10.1080/09638288.2019.1595750
Rahayu, D. C., Hakim, L., & Harefa, K. (2021). Faktor-faktor yang mempengaruhi kejadian penyakit jantung koroner di RSUD Rantau Prapat tahun 2020. PREPOTIF: Jurnal Kesehatan Masyarakat, 5(2), 1055–1057. https://doi.org/10.31004/prepotif.v5i2.2379
Razoki, N. B. S., & Rena, M. (2024). Teori dan pendalaman kasus resep sistem endokrin. Yogyakarta: Deepublish (CV Budi Utama).
Ridwan, M., Yusni, & Nurkhalis. (2020). Analisis karakteristik nyeri dada pada pasien sindroma koroner akut di Rumah Sakit Umum Daerah Dr. Zainoel Abidin Banda Aceh. Journal of Medical Science, 1(1), 20–26. https://doi.org/10.55572/jms.v1i1.5
Robbani, N. N. F., Purwaningsih, S., Rahmianti, N. D., & Ardiana, M. (2024). The role of candesartan in heart failure management: A literature review. International Journal of Scientific Advances, 5(6). https://doi.org/10.51542/ijscia.v5i6.62
Saraswati, D., & Lina, N. (2020). Faktor risiko penyakit jantung pada masyarakat di pos pembinaan terpadu (Posbindu) Puskesmas Cibeureum. Gorontalo Journal Health and Science Community, 4(1), 1–7. https://doi.org/10.35971/gojhes.v2i1.4426
Setiawati, S., Swastini, D. A., & Jaya, M. K. A. (2021). Faktor-faktor yang berpengaruh terhadap terjadinya aterosklerosis pada pasien rawat jalan di RSU Karya Dharma Husada Bros Singaraja. Jurnal Kesehatan Qamarul Huda, 9(1), 84–92. https://doi.org/10.37824/jkqh.v9i1.2021.254
Suryanegara, N. M., Suryani, Y. D., & Acang, N. (2021). Scoping review: Pengaruh kadar gula darah tidak terkontrol terhadap komplikasi makrovaskular pada pasien diabetes melitus tipe 2. Jurnal Integrasi Kesehatan dan Sains (JIKS), 3(22), 245–250.
Sіrenko, Y. M., & Torbas, O. O. (2024). Spironolactone in modern cardiology: From many years of experience to the latest evidence of effectiveness (literature review). Артериальная Гипертензия, 17(3), 7–13. https://doi.org/10.22141/2224-1485.17.3.2024.367
Tarigan, M. H. (2024). Drug related problems research phenomena in pharmacy journals in Indonesia: From patient criteria to DRPs analysis. Begibung: Jurnal Penelitian Multidisiplin, 2(2), 330–336.
Tatro, D. S. (2014). Drug interaction facts. USA: Wolters Kluwer Health.
Titin, A. W., Sri, A., & Teuku, H. (2016). Patofisiologi dasar keperawatan penyakit jantung koroner: Inflamasi vaskular. Tim UB Press.
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., Djousse, L., Elkind, M. S. V., Ferguson, J. F., Fornage, M., Khan, S. S., Kissela, B. M., Knutson, K. L., Kwan, T. W., Lackland, D. T., … Tsao, C. W. (2020). Heart disease and stroke statistics—2020 update: A report from the American Heart Association. Circulation, 141(9). https://doi.org/10.1161/CIR.0000000000000757
Wahyudi, A. (2021). Pengaruh promosi kesehatan tentang upaya pencegahan kekambuhan pasien penyakit jantung koroner di Klinik Jantung RSUD Bangil Ahmad.
Wang, W. (2024). Analysis of the effectiveness of clopidogrel combined with aspirin in the treatment of coronary heart disease in community-dwelling elderly. Journal of Clinical and Nursing Research, 8(3), 114–119. https://doi.org/10.26689/jcnr.v8i3.6425
WHO. (2019). Cardiovascular diseases. World Health Organization. https://www.who.int/health-topics/cardiovascular-diseases/. Diakses pada 14 Maret 2024.
Wihastuti, T. A., Andarini, S., & Heriansyah, T. (2016). Patofisiologi dasar keperawatan penyakit jantung koroner: Inflamasi vaskular. Universitas Brawijaya Press.
Wijaya, D. (2021). A review of the interactions of clopidogrel drugs with proton pump inhibitors (PPIs) in the treatment of cardiovascular events. Jurnal Kedokteran Meditek, 27(2), 190–196. https://doi.org/10.36452/jkdoktmeditek.v27i2.1966
Zulfa, I. M., Rahmawati, Y. A., & Anggraini, P. F. (2022). Potensi interaksi antar obat dalam peresepan rawat jalan pasien penyakit jantung akibat hipertensi. 19(1), 90–97.
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