Pemanfaatan Minyak Biji Bunga Matahari (Helianthus annuus L.) pada Formulasi Nanokrim dan Evaluasi Fisik Sediaan

Authors

  • Sri Fitrianingsih Institut Teknologi Kesehatan Cendekia Utama Kudus
  • Elisa Dyah Setiani Institut Teknologi Kesehatan Cendekia Utama Kudus
  • Yulia Pratiwi Institut Teknologi Kesehatan Cendekia Utama Kudus
  • Rakhmi Hidayati Institut Teknologi Kesehatan Cendekia Utama Kudus

DOI:

https://doi.org/10.55606/jikki.v4i3.8924

Keywords:

Antioxidant, Nanocream, Oil-in-Water Emulsion , Sunflower Seed Oil, Vitamin E

Abstract

Sunflower plants (Helianthus annuus L.) are annual plants from the Asteraceae family. This plant is cultivated as an oil producing plant. Sunflower seed oil is an excellent source of vitamin E. This vitamin is highly fat-soluble and contains flavonoid antioxidants, which prevent skin cell damage due to free radicals and help hydrate and regenerate skin cells. Nanocream is a nanoemulsion or o/w or o/m colloidal dispersion in semisolid form and consists of an oil phase dispersed into a water phase or vice versa forming droplets with a diameter of 10-100 nm. This research aims to determine the formulation and physical evaluation of sunflower seed oil nanocream (Helianthus annuus L.). The nanocream preparation was formulated into 4 formulations, namely with concentrations of 2.5%, 5% and 7.5%. The characteristics of the physical properties of nanocream include organoleptic test, homogeneity test, pH test, adhesion test, spreadability test, cream type test and viscosity test. The research results showed that the nanocream formulation had a pH value of 8.30-8.86, in the adhesion test it had a value of 4.7-11.04 seconds. In the test the spreadability of the nanocream preparation formulation had a value of 3.8-5.1 cm, in the cream type test the sunflower seed oil nanocream formulation made had the oil-in- water (O/W) emulsion type and in the viscosity test the nanocream made had the value 3.8-5.1 cm. formulation has a value of 3336.6-5455.2 cPs. There is the best nanocream preparation formulation that meets the physical characteristics of nanocream, namely F3.

References

Abdulkarim, M. F., Hameem, S. M., Abdullah, G. Z., Mahdi, E. S., Chitneni, M., Yam, M. F., Faisal, A., Salman, I. M., Ameer, O. Z., Abdulsattar, M. Z., Basri, M., & Noor, A. M. (2014). Formulation and characterization of palm oil esters based nano-cream for topical delivery of piroxicam. International Journal of Drug Delivery, 2(4), 287–298. https://doi.org/10.5138/ijdd.2010.0975.0215.02040

Budianor, B., Malahayati, S., & Saputri, R. (2022). Formulasi dan uji stabilitas sediaan krim ekstrak bunga melati putih (Jasminum sambac L.) sebagai anti jerawat. Journal Pharmaceutical Care and Sciences, 3(1), 1–13. https://doi.org/10.33859/jpcs.v3i1.204

Chandra, D., Sinaga, T. R., Manik, T. R. A., & Aruan, T. K. (2021). Formulasi nanokrim ekstrak daun katuk (Sauropus androgynus L.Merr.) sebagai pelembab kulit. Tekesnos, 3(1), 374–385.

Chintalapudi, R., Murthy, T. E. G. K., Lakshmi, K. R., & Manohar, G. G. (2015). Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine. International Journal of Pharmaceutical Investigation, 5(4), 205. https://doi.org/10.4103/2230-973X.167676

Duraivel, S., & Asm Shaheda, Rabbani Basha, et al. (2014). Formulation and evaluation of antiwrinkle activity of cream and nano emulsion of Moringa Oleifera seed oil. IOSR-JPBS, 9(4). https://doi.org/10.9790/3008-09415873

Dwandru, W. S., Brams, & Janah, N. M. (2018). Nano material. In The Fairchild Books Dictionary of Interior Design (1st ed.). Yogyakarta: UNY Press.

Fitrianingsih, S., Widodo, G. P., & Marlina, D. (2022). Variations of tween surfactant and propylene glycol cosurfactant in topical microemulsion formulation on the penetration of ibuprofen. Fitofarmaka: Jurnal Ilmiah Farmasi, 12(2), 122–134. https://doi.org/10.33751/jf.v12i2.5785

Hajrin, W., Subaidah, W. A., & Juliantoni, Y. (2024). Formulation and characterization of nanoemulsion from Brucea javanica seed extract. Formulasi dan Karakterisasi Nanoemulsi Dari Ekstrak Biji Buah Makasar (Brucea javanica (L.) Merr.), 11(1), 117–125. https://doi.org/10.24198/ijpst.v11i1.38691

Indalifiany, A., Malaka, M. H., Sahidin, F., Fristiohady, A., & Andriani, R. (2021). Formulasi dan uji stabilitas fisik nanoemulgel. Jurnal Farmasi Sains dan Praktis (JFSP), 7(3), 321–331. https://doi.org/10.31603/pharmacy.v7i3.6080

Junaidi, W. S. (2021). Formulasi dan evaluasi sediaan nanokrim dari ekstrak etanol daun bidara (Ziziphus mauritiana Lam.) sebagai anti jerawat. Industry and Higher Education, 3(1), 1689–1699.

Khotimah, N. (2018). Karakterisasi asam lemak omega hasil inklusi urea dari minyak biji bunga matahari (Helianthus annuus). Jurnal Farmasi, 4(2), 39.

Ma’arif, B., Azzahara, R., Rizki, F., Suryadinata, A., Wafi, A., Maulina, N., & Sugihantoro, H. (2023). Formulasi dan karakterisasi nanoemulsi ekstrak etanol 70% daun semanggi (Marsilea crenata C. Presl.). Medical Sains: Jurnal Ilmiah Kefarmasian, 8(2), 733–746. https://doi.org/10.37874/ms.v8i2.731

Prihatini, M., Wibowo, D. A., & Azizah, N. F. S. (2020). Formulasi dan uji stabilitas antioksidan krim nanopartikel kitosan-ekstrak etanol daun sirsak (Annona muricata L.) menggunakan metode cycling test. 88–93.

Meyliana, (2019). Formulasi dan evaluasi sediaan nanokrim minyak canola (Brassica napus L.) sebagai skin anti-aging. 24(2), 84–94.

Mudhana, A. R., & Pujiastuti, A. (2021). Pengaruh trietanolamin dan asam stearat terhadap mutu fisik dan stabilitas mekanik krim sari buah tomat. Indonesian Journal of Pharmacy and Natural Product, 4(2), 113–122. https://doi.org/10.35473/ijpnp.v4i2.1342

Nurfita, E., Mayefis, D., & Umar, S. (2021). Uji stabilitas formulasi hand and body cream ekstrak etanol kulit buah naga merah (Hylocereus lemairei). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 8(2), 125. https://doi.org/10.20473/jfiki.v8i22021.125-131

Padmadisastra, Y., Syaugi, A., & Anggia, S. (2007). Formulasi sediaan salep antikeloidal yang mengandung ekstrak terfasilitasi panas microwave dari herba pegagan (Centella asiatica (L.) Urban). Pharmaceutical Journal of Indonesia, 28–31.

Pearce, E. C. (2009). Anatomi dan fisiologi untuk paramedis (F. Yuniar, Ed.). Jakarta: PT Gramedia Pustaka Utama anggotab IKAPI.

Pratiwi, L., Fudholi, A., Martien, R., & Pramono, S. (2018). Uji stabilitas fisik dan kimia sediaan SNEDDS (Self-nanoemulsifying drug delivery system) dan nanoemulsi fraksi etil asetat kulit manggis (Garcinia mangostana L.). Traditional Medicine Journal, 23(2), 84–90. https://doi.org/10.22146/mot.28533

Reagan, M. (2021). Open access Indonesian of medical reviews. 2(1), 248–253. https://doi.org/10.37275/oaijmr.v2i1.152

Rowe, R. C., Shesky, P. J., Quinn, M. E., & et al. (2006). Handbook of Pharmaceutical Excipients (5th ed.). Pharmaceutical Press.

Rusmin. (2021). Formulasi dan uji stabilitas sediaan krim ekstrak rimpang iris (Iris pallida Lamk.) menggunakan emulgator anionik dan nonionik. Journal Pharmaceutical Care and Sciences, 5(2), 182–182.

Saryanti, D., Setiawan, I., & Safitri, R. A. (2019). Optimasi asam stearat dan tea pada formula sediaan krim ekstrak kulit pisang kepok (Musa paradisiaca L.). Jurnal Riset Kefarmasian Indonesia, 1(3), 225–237. https://doi.org/10.33759/jrki.v1i3.44

Seiler, G., & Marek, F. (2015). Germplasm resources for increasing the genetic diversity of global cultivated sunflower. Helia, 34(55), 1–20. https://doi.org/10.2298/HEL1155001S

Shoviantari, F., Liziarmezilia, Z., Bahing, A., & Agustina, L. (2019). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia Vol. 4 No. 2 Desember 2017, 60. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 6(2), 69–73. https://doi.org/10.20473/jfiki.v6i22019.69-73

Singh, S. K., Verma, P. R. P., & Razdan, B. (2010). Glibenclamide-loaded self-nanoemulsifying drug delivery system: Development and characterization. Drug Development and Industrial Pharmacy, 36(8), 933–945. https://doi.org/10.3109/03639040903585143

Tari, M., & Indriani, O. (2023). Formulasi dan uji stabilitas fisik sediaan krim ekstrak sembung rambat (Mikania micrantha Kunth). Jurnal Ilmiah Multi Science Kesehatan, 15(1), 192–211. https://doi.org/10.36729/bi.v15i1.1074

Thomas, L. (2017). Formulasi dan evaluasi sediaan nanoemulsi minyak biji bunga matahari (Helianthus annuus L.) sebagai skin anti-aging. Jurnal Farmasi, 1(1), 38.

Tungadi, R. (2020). Teknologi nano sediaan liquida dan semisolida. Jakarta: Sagung Seto.

Tungadi, R., Sy. Pakaya, M., & D.as’ali, P. W. (2023). Formulasi dan evaluasi stabilitas fisik sediaan krim senyawa astaxanthin. Indonesian Journal of Pharmaceutical Education, 3(1), 117–124. https://doi.org/10.37311/ijpe.v3i1.14612

Yanhendri, & Yenny, S. W. (2012). Berbagai bentuk sediaan topikal dalam dermatologi. 39(6), 423–430.

Zenny. (2021). Penentuan nilai SPF losion minyak bunga matahari. Herbal Medicine Journal, 4(1), 1–6.

Zubaydah, W., Magistia, L., & Indalifiany, A. (2023). Formulasi dan uji karakteristik self-nanoemulsifying drug delivery system (SNEDDS) ekstrak etanol sponge Xestospongia sp. menggunakan tween 80 sebagai surfaktan. Majalah Farmasetika, 8(2), 104. https://doi.org/10.24198/mfarmasetika.v8i2.41779

Downloads

Published

2024-11-30

How to Cite

Sri Fitrianingsih, Setiani, E. D., Pratiwi, Y., & Hidayati, R. (2024). Pemanfaatan Minyak Biji Bunga Matahari (Helianthus annuus L.) pada Formulasi Nanokrim dan Evaluasi Fisik Sediaan. Jurnal Ilmu Kedokteran Dan Kesehatan Indonesia, 4(3), 94–111. https://doi.org/10.55606/jikki.v4i3.8924

Similar Articles

<< < 1 2 3 > >> 

You may also start an advanced similarity search for this article.