Dampak Infeksi TORCH Intrauterin terhadap Perkembangan Janin dan Bayi: Tinjauan Literatur
DOI:
https://doi.org/10.55606/jikki.v6i1.10000Keywords:
Fetal Growth, Infant Development, Intrauterine Effects, Long-Term Impact, TORCH InfectionsAbstract
TORCH infections (Toxoplasmosis, Other infections, Rubella, Cytomegalovirus, and Herpes simplex) during pregnancy represent a significant health problem that can have serious impacts on fetal and neonatal health. These infections have the potential to impair fetal growth and development and to cause various complications, both in the short and long term. Therefore, a comprehensive understanding of the clinical manifestations, diagnostic processes, and long-term consequences of TORCH infections is essential to ensure optimal management for pregnant women and their infants. This article discusses the wide range of clinical symptoms associated with TORCH infections, which are often nonspecific and thus pose particular challenges in diagnosis. In addition, it addresses difficulties in establishing an accurate diagnosis, available management options, and the potential long-term risks arising from these infections. TORCH infections are known to cause intrauterine growth restriction, neurological abnormalities, sensory impairments such as vision and hearing loss, and developmental delays in children. Early detection through prenatal screening and timely intervention are key factors in minimizing adverse outcomes. As one of the major risk factors during pregnancy, TORCH infections can contribute to various serious fetal complications with long-term consequences. Therefore, optimizing prenatal care, including routine examinations, early screening, and appropriate therapy, is crucial to reduce risks and improve maternal and neonatal health outcomes.
References
Adams Waldorf, K. M., & McAdams, R. M. (2013). Influence of infection during pregnancy on fetal development. Reproduction, 146(5). https://doi.org/10.1530/REP-13-0232
al-Haddad, B. J. S., Oler, E., Armistead, B., Elsayed, N. A., Weinberger, D. R., Bernier, R., Burd, I., Kapur, R., Jacobsson, B., Wang, C., Mysorekar, I., Rajagopal, L., & Adams Waldorf, K. M. (2019). The fetal origins of mental illness. American Journal of Obstetrics and Gynecology, 221(6), 549–562. https://doi.org/10.1016/j.ajog.2019.06.013
Banatvala, J. E., & Brown, D. W. G. (2020). banatvala2004.
Bellini, C., Donarini, G., Paladini, D., Calevo, M. G., Bellini, T., Ramenghi, L. A., & Hennekam, R. C. (2015). Etiology of non-immune hydrops fetalis: An update. American Journal of Medical Genetics, Part A, 167(5), 1082–1088. https://doi.org/10.1002/ajmg.a.36988
Black, R. E., Victora, C. G., Walker, S. P., Bhutta, Z. A., Christian, P., De Onis, M., Ezzati, M., Grantham-Mcgregor, S., Katz, J., Martorell, R., & Uauy, R. (2013). Maternal and child undernutrition and overweight in low-income and middle-income countries. The Lancet, 382(9890), 427–451. https://doi.org/10.1016/S0140-6736(13)60937-X
Bollani, L., Auriti, C., Achille, C., Garofoli, F., De Rose, D. U., Meroni, V., Salvatori, G., & Tzialla, C. (2022). Congenital toxoplasmosis: The state of the art. Frontiers in Pediatrics, 10. https://doi.org/10.3389/fped.2022.894573
Boppana, S. B., Britt, W. J., Fowler, K., Hutto, S. C., James, S. H., Kimberlin, D. W., Poole, C., Ross, S. A., & Whitley, R. J. (2017). Pathogenesis of non-Zika congenital viral infections. Journal of Infectious Diseases, 216, S912–S918. https://doi.org/10.1093/infdis/jix431
Boppana, S. B., Ross, S. A., & Fowler, K. B. (2013). Congenital cytomegalovirus infection: Clinical outcome. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 57(Suppl 4). https://doi.org/10.1093/cid/cit629
Brown, Z. A., Gardella, C., Wald, A., Morrow, R. A., & Corey, L. (2005). Clinical expert series genital herpes complicating pregnancy. Green Journal, 106(4).
Centers for Disease Control and Prevention. (2016). Microcephaly in infants, Pernambuco State, Brazil, 2015. Emerging Infectious Diseases, 22(6), 1090–1093. https://doi.org/10.3201/eid2206.160062
Christian, P., Lee, S. E., Angel, M. D., Adair, L. S., Arifeen, S. E., Ashorn, P., Barros, F. C., Fall, C. H. D., Fawzi, W. W., Hao, W., Hu, G., Humphrey, J. H., Huybregts, L., Joglekar, C. V., Kariuki, S. K., Kolsteren, P., Krishnaveni, G. V., Liu, E., Martorell, R., … Black, R. E. (2013). Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries. International Journal of Epidemiology, 42(5), 1340–1355. https://doi.org/10.1093/ije/dyt109
Coyne, C. B., & Lazear, H. M. (2016). Zika virus-reigniting the TORCH. Nature Reviews Microbiology, 14(11), 707–715. https://doi.org/10.1038/nrmicro.2016.125
Deganich, M., Boudreaux, C., & Benmerzouga, I. (2023). Toxoplasmosis infection during pregnancy. Tropical Medicine and Infectious Disease, 8(1). https://doi.org/10.3390/tropicalmed8010003
Dewi, R., & Sari, P. (2019). Kehamilan dengan Infeksi TORCH. Pregnancy with Torch Infection, 3. https://doi.org/10.23960/jkunila.v3i1.pp176-181
Dominius, A. (2024). Hidrops fetalis: Etiologi dan tata laksana.
Estes, M. L., & McAllister, A. K. (n.d.). Maternal immune activation: Implications for neuropsychiatric disorders. Science.
Goderis, J., De Leenheer, E., Smets, K., Van Hoecke, H., Keymeulen, A., & Dhooge, I. (2014). Hearing loss and congenital CMV infection: A systematic review. Pediatrics, 134(5), 972–982. https://doi.org/10.1542/peds.2014-1173
Goncé, A., López, M., Guirado, L., & Salazar, L. (n.d.). Guideline: TORCH infections in pregnancy.
James, S. H., & Kimberlin, D. W. (2015). Neonatal herpes simplex virus infection. Infectious Disease Clinics of North America, 29(3), 391–400. https://doi.org/10.1016/j.idc.2015.05.001
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