Evaluasi Penggunaan dan Outcome Terapi Obat Antinyeri pada Pasien Diabetik Neuropati di RS PKU Muhammadiyah Surakarta

Authors

  • Rahayu Putri Priyanda Universitas Duta Bangsa Surakarta
  • Vivin Marwitari Rohmana Universitas Duta Bangsa Surakarta
  • Rizka Wahyu Syahputra Universitas Duta Bangsa Surakarta

DOI:

https://doi.org/10.55606/jikki.v5i3.8288

Keywords:

Diabetic Neuropathy, Neuropathic Pain, Pan Relief Tiherapy, Pain Treatment, Therapy Effectiveness

Abstract

Diabetic neuropathy is a type of neuropathic pain commonly found in patients with diabetes, resulting from damage to the central or peripheral nervous system. Neuropathic pain is one of the most frequent and distressing symptoms experienced by patients with diabetic peripheral neuropathy, affecting approximately 16% to 26% of patients. Neuropathic pain can significantly impact daily activities, self-care ability, work productivity, and sleep quality (Rivani et al., 2024). This study aimed to analyze the patterns of analgesic therapy use in patients with diabetic neuropathy and to evaluate the effectiveness of such therapy in reducing neuropathic pain levels. This study employed a retrospective observational design, using medical records data from January to December 2024. Data collected included patient characteristics, types and doses of analgesic drugs, and clinical outcomes based on pain improvement. Descriptive analysis and Chi-Square tests were performed. A total of 72 samples meeting the inclusion criteria were obtained. The evaluation of the use and outcomes of analgesic therapy in patients with diabetic neuropathy at PKU Muhammadiyah Hospital Surakarta revealed that the effectiveness of therapy was assessed based on patient outcomes after treatment. Most patients showed improvement in pain conditions, with Gabapentin demonstrating the highest effectiveness in reducing neuropathic pain. The Chi-Square test analysis on the relationship between the type of analgesic drug combination and the patient’s pain level after therapy yielded a significance value of 0.005. Since the significance value was <0.05, it can be concluded that there is a statistically significant relationship between the type of drug administered and the patient’s pain level after undergoing therapy.

References

Alammari, S. T., Al Rubaie, F. M., & Shukr, B. S. (2024). Chromogenic black dental staining in children: A case report. Cureus, 16(1), 2-5. https://doi.org/10.7759/cureus.11134

Amalia, N. M. R., & Indratono, S. (2018). Pengaruh lingkungan kerja dan motivasi kerja terhadap kinerja pegawai di Dinas Tenaga Kerja dan Sosial Kabupaten Sleman. Jurnal Fakultas Ekonomi, 046, 622-634.

Azeez, J. K., Tula, S. T., & Bello, B. (2024). Strategic human resource management in the 21st century (A review of trends and innovations). Journal of Strategic Human Resource Management, 3(1), 22-35. https://doi.org/10.30574/wjarr.2024.21.1.0105

Coad, A., & Srhoj, S. (2020). Catching gazelles with a lasso: Big data techniques for the prediction of high-growth firms. Small Business Economics, 55, 541-565.https://doi.org/10.1007/s11187-019-00203-3

de Farias, J. O., do Espírito Santo, J. A., Amorim, I. A., & Rezende, T. M. (2023). Triclosan antimicrobial activity against dental-caries-related bacteria. Brazilian Journal of Oral Science, 22, 1-7. https://doi.org/10.20396/bjos.v22i00.8668076

Dentmas Journal. (2023). Upaya peningkatan pengetahuan kesehatan gigi dan mulut masyarakat di Kelurahan Pongangan Gunungpati Kota Semarang. Dentmas Journal, 1(2), 10-18.

Ernesto, G., Ilmiawati, C., Desmawati, & et al. (2024). Pengaruh permen karet xylitol setelah terapi scaling dan root planing terhadap spesies mikrobiota oral dalam saliva anak stunting. B-Dent, 11(2), 23-32.https://doi.org/10.33854/jbd.v11i2.1711

Hidayat, N., Aulia, A. R., Fauziyyah, A. N., & Sidik, J. (2022). Black staining: An overview for the general dental practitioner. British Dental Journal, 232(12), 857-860.https://doi.org/10.1038/s41415-022-4345-0

Jansena, J. J. P., Heavey, C., Moma, T. J. M., Simsek, Z., & Zahrad, S. A. (2023). Scaling-up: Building, leading and sustaining rapid growth over time. Journal of Operations Management, 41(3), 203-215. https://doi.org/10.1111/joms.12910

Kadir, A. (2021). Analisis pengaruh kompetensi dan motivasi kerja terhadap tingkat kepuasan masyarakat pada pelayanan terpadu satu pintu kantor kementerian agama Kabupaten Tapin di Rantau. Jurnal Sains Sosio Humaniora, 5(2), 750-758.https://doi.org/10.22437/jssh.v5i2.15781

Khuong, M. N., & Yen, V. H. (2014). Investigate the effects of job stress on employee job performance. International Journal of Trade, Economics, and Finance, 5(2), 123-129.

Lestari, D., & Susanto, H. (2021). Job satisfaction as mediator: Work environment and HR development. Jurnal Manajemen, 6(2), 110-118.

Lestari, S. (2022). Pengaruh citra destinasi, fasilitas wisata terhadap minat berkunjung ulang (Studi kasus wisatawan Pantai Klayar Pacitan). EXERO: Journal of Research in Hospitality, 10(1), 50-60.https://doi.org/10.24071/exero.v5i1.5037

Merlin, E., Salio, C., & Ferrini, F. (2024). Painful diabetic neuropathy: Sex-specific mechanisms and differences from animal models to clinical outcomes. Cells, 13(23), 1-16.https://doi.org/10.3390/cells13232024

Pamungkas, R. A. (2021). Panduan praktis screening risiko diabetes. Jurnal Ilmu Kesehatan, 8(2), 145-158.

Perkeni. (2021). Pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia. In Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia - 2021 (pp. 1-119). PB. PERKENI.

Rachmantoko, R., Afif, Z., Rahmawati, D., Rakhmatiar, R., & Nandar, K. (2021). Diabetic neuropathic pain. JPHV (Journal of Pain, Vertigo, and Headache), 2(1), 8-12.https://doi.org/10.21776/ub.jphv.2021.002.01.3

Resti, H. Y., & Cahyati, W. H. (2022). Kejadian diabetes melitus pada usia produktif di Puskesmas Kecamatan Pasar Rebo. Higeia Journal of Public Health Research and Development, 6(3), 350-361. http://journal.unnes.ac.id/sju/index.php/higeia

Rivani, S., Faizah, N., & Hasanudin, M. N. (2024). Evaluasi penggunaan terapi obat antinyeri pada pasien diabetik neuropatik di Instalasi Rawat Jalan RSU Queen Latifa Kulon Progo. Kunir: Jurnal Farmasi Indonesia, 2(1), 40-49.https://doi.org/10.36308/kjfi.v2i1.623

Setiati, S., Alwi, I., Sudoyo, A. W., & Setiyohadi, B. (2017). Ilmu Penyakit Dalam Diabetes Melitus. Edisi 8. Jakarta: Internal Medicine Society.

Siagian, L. O. (2016). Hubungan kontrol glikemik pengidap diabetes melitus tipe 2 dengan kejadian neuropati diabetik di RSUD Dr. Pirngadi Kota Medan. Jurnal Ilmiah Maksitek, 1(2), 1-23.

Sihotang, H. T. (2017). Perancangan aplikasi sistem pakar diagnosa diabetes dengan metode Bayes. Jurnal Manik Penusa, 1(1), 36-41.

Suharni, S., Zulkarnaini, A., & Kusnadi, D. T. (2021). Kadar HbA1C pada pasien diabetes melitus tipe 2 dengan komplikasi neuropati diabetik di RSI Siti Rahmah Padang tahun 2019-2020. Baiturrahmah Medical Journal, 1(2), 32-36.https://doi.org/10.56260/sciena.v1i2.38

Sumardiyono, B., & Suri, I. K. (2022). Neuropati diabetika kontribusi karakteristik individu, lama sakit, merokok. Jurnal Kesehatan Masyarakat Indonesia, 17(2), 1-5. https://jurnal.unimus.ac.id/index.php/jkmi

Sun, Y., Lai, M. S., & Lu, C. J. (2017). Effectiveness of vitamin B12 on diabetic neuropathy: Systematic review of clinical controlled trials. Acta Neurologica Taiwanica, 14(2), 48-54.

Syahbana, K. F., Dwimartyono, F., Dahliah, N., Nurhikmawati, & Wahab, M. I. (2023). Efektifitas terapi medikamentosa pemberian gabapentinoid untuk penanggulangan rasa nyeri pada neuropati diabetik. Fakumi Medical Journal: Jurnal Mahasiswa Kedokteran, 2(12), 893-904. https://doi.org/10.33096/fmj.v2i12.164

Tambirang, R., Wiyono, W., & Mamarimbing, M. (2019). Evaluasi penggunaan dan outcome terapi obat antinyeri pada pasien diabetik neuropati di Instalasi Rawat Inap RSUP Prof. Dr. R. D. Kandou Manado. Pharmacon, 7(3), 76-88.

Tesfaye, S., Sloan, G., Petrie, J., White, D., Bradburn, M., Young, T., Rajbhandari, S., Sharma, S., Rayman, G., Gouni, R., Alam, U., Julious, S. A., Cooper, C., Loban, A., Sutherland, K., Glover, R., Waterhouse, S., Turton, E., Horspool, M., … Selvarajah, D. (2022). Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: The OPTION-DM RCT. Health Technology Assessment, 26(39).https://doi.org/10.3310/RXUO6757

Toth, C. (2018). Gabapentin: Latest safety evidence and clinical implications for the management of neuropathic pain. Therapeutic Advances in Drug Safety, 5(1), 38-56.https://doi.org/10.1177/2042098613505614

Trisna Lestari, L. K., Purwata, E., & Putra, I. P. (2016). Terapi insulin menurunkan kejadian nyeri neuropati diabetik dibandingkan dengan oral anti-diabetes pada penderita diabetes melitus tipe 2. Medicina, 47(1), 67-74.https://doi.org/10.15562/medicina.v47i1.80

WHO. (2018). Noncommunicable disease. In Heart of Africa: Clinical profile of an evolving burden of heart disease in Africa (pp. 1-10).https://doi.org/10.1002/9781119097136.part5

WHO. (2020). The elimination of cancer. Cancer Country Profile, 1(2), 180-181.https://doi.org/10.1016/S0366-0850(07)80117-7

Wulandari, A., Luthfiyanti, N., & Kusumaningtyas. (2024). Evaluasi ketepatan pemilihan obat dan outcome terapi pada pasien diabetes melitus tipe II rawat jalan di RSUD Dr. Moewardi Surakarta. Prepotif: Jurnal Kesehatan Masyarakat, 8, 3733-3748.https://doi.org/10.31004/prepotif.v8i2.28454

Yang, Y., Zhao, B., Wang, Y., Lan, H., Liu, X., Hu, Y., & Cao, P. (2025). Diabetic neuropathy: Cutting-edge research and future directions. Signal Transduction and Targeted Therapy, 10(1).https://doi.org/10.1038/s41392-025-02175-1

Yuneldi, A., Ibnu, P., & Surbakti, K. (2018). Perbedaan efek analgesik amitriptilin, gabapentin, dan pregabalin pada neuropati diabetik dan neuralgia trigeminal. Jurnal Kedokteran Gigi, 35(2), 109-115.https://doi.org/10.52386/neurona.v35i2.19

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Published

2025-09-17

How to Cite

Rahayu Putri Priyanda, Vivin Marwitari Rohmana, & Rizka Wahyu Syahputra. (2025). Evaluasi Penggunaan dan Outcome Terapi Obat Antinyeri pada Pasien Diabetik Neuropati di RS PKU Muhammadiyah Surakarta. Jurnal Ilmu Kedokteran Dan Kesehatan Indonesia, 5(3), 478–499. https://doi.org/10.55606/jikki.v5i3.8288

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