Analisis Gangguan Cairan Elektrolit dan Hipovolemia pada Penyakit Demam Berdarah Dengue (DBD)

(Literatur Review)

Authors

  • Hasna Sari Kusnandar Universitas Pendidikan Indonesia
  • Elsa Devina Seftiani Universitas Pendidikan Indonesia
  • Muhammad Fhaisal Nur Halim Universitas Pendidikan Indonesia
  • Nazwa Rahma Putri Universitas Pendidikan Indonesia
  • Rendi Rizki Priyanto Universitas Pendidikan Indonesia
  • Tri Ayuni Universitas Pendidikan Indonesia
  • Faiza Zahra Amelia Universitas Pendidikan Indonesia
  • Zahra Arifah Universitas Pendidikan Indonesia
  • Aura Rukmana Universitas Pendidikan Indonesia
  • Amanda Saskia Raika Putri Universitas Pendidikan Indonesia
  • Popi Sopiah Universitas Pendidikan Indonesia

DOI:

https://doi.org/10.55606/jikki.v6i2.11158

Keywords:

Dengue Hemorrhagic Fever, Electrolyte Imbalance, Fluid Balance, Hypovolemia, Plasma Leakage

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health problem in tropical countries, including Indonesia, due to its high incidence and risk of severe complications. One of the most critical complications is hypovolemia, which is closely associated with fluid and electrolyte imbalance caused by plasma leakage. This study aimed to analyze the relationship between fluid imbalance, electrolyte disturbances, and hypovolemia in patients with DHF using a narrative literature review approach. Data were collected from several scientific databases, including Google Scholar, PubMed, Semantic Scholar, and Crossref, covering publications from 2021 to 2025. A total of 894 articles were identified in the initial search, and 6 articles that met the inclusion criteria were further analyzed. The findings showed that increased capillary permeability plays a key role in plasma leakage, leading to decreased intravascular volume and hypovolemia. In addition, electrolyte imbalances, particularly hyponatremia and hypokalemia, were frequently reported and associated with disease severity. These conditions may contribute to serious complications such as shock and organ dysfunction if not properly managed. Therefore, early detection, careful monitoring of fluid balance, and appropriate clinical management are essential to prevent complications and improve patient outcomes.

References

Ariyanti, M., & Anggraini, D. (2022). Aspek klinis dan pemeriksaan laboratorium untuk diagnosis demam berdarah dengue. Scientific Journal, 1(1), 70-78. https://doi.org/10.56260/sciena.v1i1.13

Artanti, N. P., Intan, N., Wiguna, P., Luh, N., & Pranena, P. (2026). Stres akademik dan respons psikologis pada mahasiswa di masa tekanan akademik tinggi: Studi kualitatif tidak dapat dipahami secara sederhana hanya melalui satu variabel penyebab. 5(November 2025).

Awaliah, N., & Widiantoro, R. (2024). Nursing care for patients with dengue hemorrhagic fever with hypovolemia. Journal of Nursing and Health, 1(2), 1-15.

Ayyub, A., Yousaf, S., Khan, A. A., Dawood, S., Babar, S., & Khan, A. (2025). Electrolyte balance in dengue viral infection: Exploring the "hidden reef." Infectious Diseases Journal of Pakistan, 34(4), 252-257. https://doi.org/10.61529/idjp.v34i4.474

Carras, M., Maillard, O., Cousty, J., Gérardin, P., Boukerrou, M., Raffray, L., Mavingui, P., Poubeau, P., Cabie, A., & Bertolotti, A. (2023). Associated risk factors of severe dengue in Reunion Island: A prospective cohort study. PLoS Neglected Tropical Diseases, 17(4), 1-12. https://doi.org/10.1371/journal.pntd.0011260

Chairani Sitepu, I., Olivia, N., & Syafrinanda, V. (2023). Pendidikan kesehatan tentang pemenuhan kebutuhan cairan pada pasien DHF di Rumah Sakit TK II Putri Hijau Medan. SENTRI: Jurnal Riset Ilmiah, 2(11), 4565-4570. https://doi.org/10.55681/sentri.v2i11.1702

Dengue. (2025, August 21). World Health Organization. https://www.who.int/mega-menu/health-topics/popular/dengue?

Dinesh Reddy, P., & Kumar, P. J. (2025). Serum electrolyte imbalance in dengue and the correlation of sodium with the severity of dengue infection. International Journal of Scientific Research, 14(5), 53-56. https://doi.org/10.36106/ijsr

Effiong, M. G., Yakubu, A. O., Lawal, F. I., Ojoh, U. H., & Adeniyi, T. O. (2026). Dengue virus infection and Guillain-Barré syndrome: A systematic review of clinical characteristics, outcomes, and predictors of severity. BMC Infectious Diseases, 26(133), 1-11. https://doi.org/10.1186/s12879-025-12428-7

Fadila, M., & Argarini, D. (2023). Analisis asuhan keperawatan melalui intervensi manajemen hipovolemia pada pasien An. A dan An. R dengan dengue hemoragic fever di RS Marinir Cilandak. Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM), 6(4), 1312-1323. https://doi.org/10.33024/jkpm.v6i4.8950

Khanam, A., Gutiérrez-barbosa, H., Lyke, K. E., & Chua, J. V. (2022). Patogenesis yang dimediasi sistem kekebalan dalam infeksi virus dengue.

Meiliawati, A. C., & Hamid, M. A. (2025). Manajemen hipovolemia pada anak dengan dengue hemorhagic fever (DHF) di ruang anak RSD Kalisat. Jurnal Kesehatan Republik Indonesia, 2(8), 311-316. https://jurnal.intekom.id/index.php/jkri

Nimra Fatima, Muhammad Ashfaq, Wajid Hussain, Mariam Raza, & Atiya Anwar. (2025a). Electrolyte imbalance and its association with the severity of dengue fever. The Professional Medical Journal, 32(10), 1272-1279. https://doi.org/10.29309/tpmj/2025.32.10.9936

Nimra Fatima, Muhammad Ashfaq, Wajid Hussain, Mariam Raza, & Atiya Anwar. (2025b). Electrolyte imbalance and its association with the severity of dengue fever. The Professional Medical Journal, 32(10), 1272-1279. https://doi.org/10.29309/tpmj/2025.32.10.9936

Nugraheni, E., Rizqoh, D., & Sundari, M. (2023). Manifestasi klinis demam berdarah dengue (DBD). Jurnal Kedokteran Dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 10(3), 267-274. https://doi.org/10.32539/jkk.v10i3.21425

Rambe, M. L., Joshua, S., & Tua, H. (2025). Hubungan perubahan nilai hematokrit dengan tingkat keparahan demam berdarah dengue pada di RSUD Pandan Kabupaten Tapanuli Tengah Tahun 2024. Jurnal Pendidikan Indonesia, 6(11), 5106-5114. https://doi.org/10.59141/japendi.v6i11.8845

Suroso, H., Qomariah, S. N., Bakar, A., & Paraswati, M. D. (2025). Peran tenaga kesehatan. Community Development in Health Journal, 3(1), 20-28. https://doi.org/10.37036/cdhj.v3i1.610

Tamia Marisa, Y., Ahmad, A., Padang, N., Batang Masang Nomor, Alan, Balok, B., Aur Birugo Tigo Baleh, K., Bukittinggi, K., & Barat, S. (2024). Dengue shock syndrome. Human Care Journal, 9(1), 115-125. https://sinta.kemdikbud.go.id/journals/profile/5436

Waspada demam berdarah dengue. (2026, February 2). Kementerian Kesehatan Republik Indonesia. https://pusatkrisis.kemkes.go.id/waspada-demam-berdarah-dengue

Downloads

Published

2026-04-13

How to Cite

Hasna Sari Kusnandar, Elsa Devina Seftiani, Muhammad Fhaisal Nur Halim, Nazwa Rahma Putri, Rendi Rizki Priyanto, Tri Ayuni, … Popi Sopiah. (2026). Analisis Gangguan Cairan Elektrolit dan Hipovolemia pada Penyakit Demam Berdarah Dengue (DBD): (Literatur Review). Jurnal Ilmu Kedokteran Dan Kesehatan Indonesia, 6(2), 474–485. https://doi.org/10.55606/jikki.v6i2.11158

Similar Articles

<< < 1 2 3 4 

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)