Gambaran dan Nilai Rata-rata Prostate Specific Antigen Pasien yang dilakukan Transurethral Resection of the Prostate di RSUD Dr. Achmad Mochtar Bukittinggi

Authors

  • Muhammad Fachriza Busril Universitas Andalas
  • Etriyel MYH Universitas Andalas
  • Meinapuri M Universitas Andalas
  • Alvarino Alvarino Universitas Andalas
  • Mulyani H Universitas Andalas
  • Novita E Universitas Andalas

DOI:

https://doi.org/10.55606/jikki.v5i2.6038

Keywords:

Histopathology, PSA, TURP

Abstract

Prostate-specific antigen (PSA) is a serine protease produced by the prostate epithelium. PSA is a product of prostate epithelial cells that functions to liquefy semen, thereby enhancing sperm motility. This study is an analytical study with a cross-sectional design, utilizing secondary data from the medical records of patients who underwent transurethral resection of the prostate (TURP) at Dr. Achmad Mochtar General Hospital, Bukittinggi, from 2022 to 2023. The results of the study showed that the most commonly found PSA range category was 4-20 ng/ml, with a percentage of 40.2%. Furthermore, the study found that the highest average PSA levels were observed in patients with prostate cancer, with a mean value of 53.39 ng/ml. Based on these findings, it can be concluded that monitoring PSA levels plays a crucial role in the early diagnosis and management of prostate cancer and can serve as an important reference in future prevention and treatment efforts.

References

Asril, F., MYH, E., & Yunir, P. E. (2024). The effect of tamsulosin 0.4 mg administration towards alteration of prostate specific antigen (PSA) levels in benign prostatic hyperplasia (BPH) patients in Padang City. Indonesian Journal of Urology, 31(2). https://doi.org/10.32421/juri.v31i2.870

Atan, A., & Guzel, O. (2014). How should prostate specific antigen be interpreted? Türk Üroloji Dergisi/Turkish Journal of Urology, 39(3), 188–193. https://doi.org/10.5152/tud.2013.038

Damayanti, R., Wulandari, D. I., & Setiati, S. (2019). Hubungan kadar PSA dengan volume prostat pada pasien benign prostatic hyperplasia (BPH) di RSUP Dr. Sardjito Yogyakarta. Jurnal Kedokteran UGM, 55(1), 23–29. https://doi.org/10.22146/jkugm.45782

Jue, J. S., Barboza, M. P., Prakash, N. S., Venkatramani, V., Sinha, V. R., Pavan, N., Nahar, B., Kanabur, P., Ahdoot, M., Dong, Y., Satyanarayana, R., Parekh, D. J., & Punnen, S. (2017). Re-examining prostate-specific antigen (PSA) density: Defining the optimal PSA range and patients for using PSA density to predict prostate cancer using extended template biopsy. Urology, 105, 123–128. https://doi.org/10.1016/j.urology.2017.04.015

Khan, F. U., Ihsan, A. U., Khan, H. U., Jana, R., Wazir, J., Khongorzul, P., Waqar, M., & Zhou, X. (2017). Comprehensive overview of prostatitis. Biomedicine & Pharmacotherapy, 94, 1064–1076. https://doi.org/10.1016/j.biopha.2017.08.016

Litbangkes. (2018). Riset kesehatan dasar. Kementerian Kesehatan Republik Indonesia.

Ramadhan, F., & Fathoni, M. (2020). Pola kejadian penyakit prostat dan nilai PSA pada lansia di RSUD Dr. Soetomo Surabaya. Jurnal Ilmu Kesehatan Masyarakat, 11(2), 112–117. https://doi.org/10.26553/jikm.2020.11.2.112-117

Sarwar, S., Adil, M. A. M., Nyamath, P., & Ishaq, M. (2017). Biomarkers of prostatic cancer: An attempt to categorize patients into prostatic carcinoma, benign prostatic hyperplasia, or prostatitis based on serum prostate specific antigen, prostatic acid phosphatase, calcium, and phosphorus. Prostate Cancer, 2017, 1–7. https://doi.org/10.1155/2017/5687212

Suryadi, A., & Santoso, B. (2018). Analisis hubungan kadar PSA dengan derajat keparahan hipertrofi prostat jinak. Jurnal Biomedik, 10(2), 87–93. https://doi.org/10.35790/jbm.10.2.2018.22104

Thompson, I. M., Pauler, D. K., Goodman, P. J., Tangen, C. M., Lucia, M. S., Parnes, H. L., Minasian, L. M., Ford, L. G., Lippman, S. M., Crawford, E. D., Crowley, J. J., & Coltman, C. A. (2004). Prevalence of prostate cancer among men with a prostate-specific antigen level ≤4.0 ng per milliliter. New England Journal of Medicine, 350(22), 2239–2246. https://doi.org/10.1056/NEJMoa031918

Toivanen, R., & Shen, M. M. (2017). Prostate organogenesis: Tissue induction, hormonal regulation and cell type specification. Development, 144(8), 1382–1398. https://doi.org/10.1242/dev.148270

World Health Organization. (2020). Global cancer observatory (pp. 1–2). https://gco.iarc.fr/

Wulansari, N. S., & Marindawati, M. (2020). Profil prostate spesific antigen (PSA) pada penyakit prostat di Rumah Sakit Umum Daerah Cengkareng Jakarta Barat. Muhammadiyah Journal of Geriatric, 1(1), 18–22. https://doi.org/10.24853/mujg.1.1.18-22

Xu, X.-F., Liu, G.-X., Guo, Y.-S., Zhu, H.-Y., He, D.-L., Qiao, X.-M., & Li, X.-H. (2021). Global, regional, and national incidence and year lived with disability for benign prostatic hyperplasia from 1990 to 2019. American Journal of Men’s Health, 15(4). https://doi.org/10.1177/15579883211036786

Yilmaz, S. N., & Yildiz, A. (2014). PSA, PSA derivatives, proPSA and prostate health index in the diagnosis of prostate cancer. Türk Üroloji Dergisi/Turkish Journal of Urology, 40(2), 82–88. https://doi.org/10.5152/tud.2014.94547

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Published

2025-05-23

How to Cite

Muhammad Fachriza Busril, Etriyel MYH, Meinapuri M, Alvarino Alvarino, Mulyani H, & Novita E. (2025). Gambaran dan Nilai Rata-rata Prostate Specific Antigen Pasien yang dilakukan Transurethral Resection of the Prostate di RSUD Dr. Achmad Mochtar Bukittinggi. Jurnal Ilmu Kedokteran Dan Kesehatan Indonesia, 5(2), 49–53. https://doi.org/10.55606/jikki.v5i2.6038

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Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia

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